Version 5.4
Homo sapiens Protein: TTLL11
Summary
InnateDB Protein IDBP-83712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTLL11
Protein Name tubulin tyrosine ligase-like family, member 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362881
InnateDB Gene IDBG-83704 (TTLL11)
Protein Structure
UniProt Annotation
Function Polyglutamase which preferentially modifies alpha- tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. {ECO:0000250, ECO:0000269PubMed:22493317}.
Subcellular Localization Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016874 ligase activity
Biological Process
GO:0006464 cellular protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
Protein Structure and Domains
PDB ID
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHH1
PhosphoSite PhosphoSite-Q8NHH1
TrEMBL Q8NHH0
UniProt Splice Variant
Entrez Gene 158135
UniGene Hs.640663
RefSeq NP_919228
HUGO HGNC:18113
OMIM
CCDS CCDS6834
HPRD 10047
IMGT
EMBL AF521886 AF521887 AL162423 AL442634 AL445587
GenPept AAM81328 AAM81329 CAH73979 CAI39985 CAI40706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca