InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF4

Summary

InnateDB Protein

IDBP-83801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF4

Protein Name

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa

Synonyms

TAF2C; TAF2C1; TAF4A; TAFII130; TAFII135;

Species

Homo sapiens

Ensembl Protein

ENSP00000252996

InnateDB Gene

IDBG-83797 (TAF4)

Protein Structure

UniProt Annotation

Function

Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001541	ovarian follicle development
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm
GO:0033276	transcription factor TFTC complex
GO:0071339	MLL1 complex