InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCUBE3

Summary

InnateDB Protein

IDBP-83837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCUBE3

Protein Name

signal peptide, CUB domain, EGF-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274938

InnateDB Gene

IDBG-83835 (SCUBE3)

Protein Structure

UniProt Annotation

Function

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. {ECO:0000269PubMed:21441952}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15234972}. Cell surface {ECO:0000269PubMed:15234972}.

Disease Associations

Tissue Specificity

Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells. {ECO:0000269PubMed:15234972, ECO:0000269PubMed:21441952}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

PFAM

PF00008
PF00431
PF07645
PF07699

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IX30