InnateDB Protein
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IDBP-83918.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSMA7
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Protein Name
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proteasome (prosome, macropain) subunit, alpha type, 7
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Synonyms
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C6; HSPC; RC6-1; XAPC7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359898
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InnateDB Gene
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IDBG-83912 (PSMA7)
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Protein Structure
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Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269PubMed:11389899, ECO:0000269PubMed:11713272, ECO:0000269PubMed:12119296, ECO:0000269PubMed:19442227, ECO:0000269PubMed:19734229}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
138
[view]
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Protein-Protein |
134
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
4
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000209
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protein polyubiquitination
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GO:0000278
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mitotic cell cycle
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0006521
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regulation of cellular amino acid metabolic process
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GO:0006915
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apoptotic process
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GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0042981
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regulation of apoptotic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0044281
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small molecule metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051603
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proteolysis involved in cellular protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001353
Proteasome, subunit alpha/beta
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF00227
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14818
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PhosphoSite |
PhosphoSite-O14818
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5688
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UniGene |
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RefSeq |
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HUGO |
HGNC:9536
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OMIM |
606607
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CCDS |
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HPRD |
05967
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IMGT |
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EMBL |
AF022815
AF054185
AK312025
AL078633
BC004427
BI906714
BT007165
CH471077
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GenPept |
AAB81515
AAC99402
AAH04427
AAP35829
BAG34962
CAC04017
CAC04018
EAW75398
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