InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKAP

Summary

InnateDB Protein

IDBP-84228.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKAP

Protein Name

NFKB activating protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360464

InnateDB Gene

IDBG-84226 (NKAP)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269PubMed:14550261, ECO:0000269PubMed:19409814}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14550261}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0019827	stem cell maintenance
GO:0030097	hemopoiesis
GO:0030851	granulocyte differentiation
GO:0033077	T cell differentiation in thymus
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0071425	hematopoietic stem cell proliferation