InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFA10

Summary

InnateDB Protein

IDBP-84631.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA10

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa

Synonyms

CI-42k; CI-42KD;

Species

Homo sapiens

Ensembl Protein

ENSP00000252711

InnateDB Gene

IDBG-84629 (NDUFA10)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006139	nucleobase-containing compound metabolic process
GO:0022904	respiratory electron transport chain
GO:0042493	response to drug
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR002624 Deoxynucleoside kinase
IPR015828 NADH:ubiquinone oxidoreductase, 42kDa subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01712

PRINTS

PIRSF

PIRSF000705
PIRSF000543

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95299