InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DVL1

Summary

InnateDB Protein

IDBP-85127.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DVL1

Protein Name

dishevelled, dsh homolog 1 (Drosophila)

Synonyms

DVL; DVL1L1; DVL1P1;

Species

Homo sapiens

Ensembl Protein

ENSP00000368169

InnateDB Gene

IDBG-85121 (DVL1)

Protein Structure

UniProt Annotation

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0001932	regulation of protein phosphorylation
GO:0001933	negative regulation of protein phosphorylation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0007269	neurotransmitter secretion
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0010976	positive regulation of neuron projection development
GO:0021915	neural tube development
GO:0022007	convergent extension involved in neural plate elongation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031122	cytoplasmic microtubule organization
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0035176	social behavior
GO:0035372	protein localization to microtubule
GO:0035556	intracellular signal transduction
GO:0043113	receptor clustering
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048668	collateral sprouting
GO:0048675	axon extension
GO:0048813	dendrite morphogenesis
GO:0050808	synapse organization
GO:0060026	convergent extension
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060134	prepulse inhibition
GO:0071340	skeletal muscle acetylcholine-gated channel clustering
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005874	microtubule
GO:0005938	cell cortex
GO:0015630	microtubule cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0043025	neuronal cell body
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000591 DEP domain
IPR001158 DIX domain
IPR001478 PDZ domain
IPR003351 Dishevelled protein domain
IPR008339 Dishevelled family
IPR024580 Dishevelled C-terminal

PFAM

PF00610
PF00778
PF00595
PF13180
PF02377
PF12316

PRINTS

PR01760

PIRSF

SMART

SM00049
SM00021
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt