InnateDB Protein
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IDBP-85932.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARFGAP1
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Protein Name
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ADP-ribosylation factor GTPase activating protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359298
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InnateDB Gene
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IDBG-85926 (ARFGAP1)
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Protein Structure
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Function |
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with the Golgi complex. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006890
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retrograde vesicle-mediated transport, Golgi to ER
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GO:0006987
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activation of signaling protein activity involved in unfolded protein response
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GO:0015031
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protein transport
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0032312
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regulation of ARF GTPase activity
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GO:0043547
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positive regulation of GTPase activity
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GO:0044267
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cellular protein metabolic process
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GO:0048205
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COPI coating of Golgi vesicle
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GO:0061024
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membrane organization
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Cellular Component |
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PDB ID |
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InterPro |
IPR001164
Arf GTPase activating protein
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PFAM |
PF01412
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PRINTS |
PR00405
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PIRSF |
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SMART |
SM00105
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N6T3
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PhosphoSite |
PhosphoSite-Q8N6T3
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TrEMBL |
F8VWB3
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UniProt Splice Variant |
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Entrez Gene |
55738
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UniGene |
Hs.740420
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RefSeq |
NP_001268411
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HUGO |
HGNC:15852
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OMIM |
608377
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CCDS |
CCDS63326
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HPRD |
06443
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IMGT |
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EMBL |
AB015340
AK001629
AK027268
AK027441
AK303454
AL121827
AL137744
BC000786
BC006085
BC011876
BC028233
CH471077
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GenPept |
AAH00786
AAH06085
AAH11876
AAH28233
BAA88117
BAA91796
BAB55009
BAB55113
BAH13964
CAB70901
CAX12645
EAW75292
EAW75294
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