Version 5.4
Homo sapiens Protein: SLC25A28
Summary
InnateDB Protein IDBP-86045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A28
Protein Name solute carrier family 25, member 28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359526
InnateDB Gene IDBG-86043 (SLC25A28)
Protein Structure
UniProt Annotation
Function Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:11297739}; Multi-pass membrane protein {ECO:0000269PubMed:11297739}. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO:0000269PubMed:11297739}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006811 ion transport
GO:0044281 small molecule metabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96A46
PhosphoSite PhosphoSite-Q96A46
TrEMBL
UniProt Splice Variant
Entrez Gene 81894
UniGene Hs.619091
RefSeq NP_112489
HUGO HGNC:23472
OMIM 609767
CCDS CCDS41559
HPRD
IMGT
EMBL AF267854 AF327402 AF327403 AJ303077 AJ303078 AL353719 AL831943 BC047312 BC058937 BC076399 BC094821
GenPept AAG44723 AAH47312 AAH58937 AAH76399 AAH94821 AAK49519 AAK49520 CAC27996 CAC27997 CAH10774 CAI16900 CAI16901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca