Version 5.4
Homo sapiens Protein: KCNQ2
Summary
InnateDB Protein IDBP-86076.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNQ2
Protein Name potassium voltage-gated channel, KQT-like subfamily, member 2
Synonyms BFNC; BFNS1; EBN; EBN1; EIEE7; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1;
Species Homo sapiens
Ensembl Protein ENSP00000339611
InnateDB Gene IDBG-86058 (KCNQ2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0030506 ankyrin binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0033268 node of Ranvier
GO:0043194 axon initial segment
Protein Structure and Domains
PDB ID
InterPro IPR003091 Potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR003947 Potassium channel, voltage dependent, KCNQ2
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
IPR020969 Ankyrin-G binding site
PFAM PF00520
PF07885
PF03520
PF11956
PRINTS PR00169
PR01459
PR01461
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43526
PhosphoSite PhosphoSite-O43526
TrEMBL
UniProt Splice Variant
Entrez Gene 3785
UniGene Hs.740010
RefSeq NP_742106
HUGO HGNC:6296
OMIM 602235
CCDS CCDS46629
HPRD 03757
IMGT
EMBL AF033348 AF074247 AF110020 AL121827 AL121829 AL353658 BC000699 D82346 Y15065
GenPept AAB97315 AAC25921 AAD16988 AAH00699 BAA11557 CAA75348 CAH72958 CAH72959 CAI95054 CAI95740 CAI95744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca