Version 5.4
Homo sapiens Protein: GPR119
Summary
InnateDB Protein IDBP-86150.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR119
Protein Name G protein-coupled receptor 119
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000276218
InnateDB Gene IDBG-86148 (GPR119)
Protein Structure
UniProt Annotation
Function Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. {ECO:0000269PubMed:16517404}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Predominantly expressed in the pancreas, especially in the islets. {ECO:0000269PubMed:15607732}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0031210 phosphatidylcholine binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030073 insulin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDV5
PhosphoSite PhosphoSite-Q8TDV5
TrEMBL
UniProt Splice Variant
Entrez Gene 139760
UniGene Hs.496762
RefSeq NP_848566
HUGO HGNC:19060
OMIM 300513
CCDS CCDS14625
HPRD 06579
IMGT
EMBL AB065936 AB083584 AL035423 AY288416 BC095502 BC101166 BC101167 BC101168 BC126179 BC126181
GenPept AAH95502 AAI01167 AAI01168 AAI01169 AAI26180 AAI26182 AAP72125 BAB89297 BAC06151 CAI42442

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca