InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AK1

Summary

InnateDB Protein

IDBP-86695.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK1

Protein Name

adenylate kinase 1

Synonyms

HTL-S-58j;

Species

Homo sapiens

Ensembl Protein

ENSP00000362249

InnateDB Gene

IDBG-86687 (AK1)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255HAMAP-Rule:MF_03171, ECO:0000269PubMed:23416111}.

Subcellular Localization

Cytoplasm.

Disease Associations

Hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631]: A disease characterized by hemolytic anemia and undetectable erythrocyte adenylate kinase activity. {ECO:0000269PubMed:12649162, ECO:0000269PubMed:2542324, ECO:0000269PubMed:9432020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006267 Adenylate kinase, isozyme 1/5
IPR010488 Zeta toxin domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF06414

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00568