InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTMR7

Summary

InnateDB Protein

IDBP-8672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR7

Protein Name

myotubularin related protein 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000180173

InnateDB Gene

IDBG-8670 (MTMR7)

Protein Structure

UniProt Annotation

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. {ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16787938}.

Disease Associations

Tissue Specificity

Expressed specifically in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR010569 Myotubularin-like phosphatase domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF06602

PRINTS

PIRSF

SMART

SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y216