InnateDB Protein
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IDBP-86797.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TFEB
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Protein Name
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transcription factor EB
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Synonyms
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ALPHATFEB; BHLHE35; TCFEB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230323
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InnateDB Gene
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IDBG-86793 (TFEB)
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Protein Structure
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Function |
Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. {ECO:0000269PubMed:19556463, ECO:0000269PubMed:23434374}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802
Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
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PFAM |
PF00010
PF11851
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P19484
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PhosphoSite |
PhosphoSite-P19484
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TrEMBL |
Q86WB1
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UniProt Splice Variant |
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Entrez Gene |
7942
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UniGene |
Hs.485360
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RefSeq |
NP_009093
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HUGO |
HGNC:11753
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OMIM |
600744
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CCDS |
CCDS4858
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HPRD |
02847
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IMGT |
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EMBL |
AJ535461
AJ608786
AJ608787
AJ608790
AJ608791
AJ608793
AK095061
AL035588
AL365205
BC006225
BC032448
CH471081
M33782
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GenPept |
AAA36730
AAH06225
AAH32448
BAG52979
CAD59560
CAD92604
CAE77672
CAE77675
CAE77676
CAE77678
CAE77681
EAX04056
EAX04058
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