Version 5.4
Homo sapiens Protein: PGC
Summary
InnateDB Protein IDBP-86832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGC
Protein Name progastricsin (pepsinogen C)
Synonyms PEPC; PGII;
Species Homo sapiens
Ensembl Protein ENSP00000362116
InnateDB Gene IDBG-86830 (PGC)
Protein Structure
UniProt Annotation
Function Hydrolyzes a variety of proteins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20142
PhosphoSite PhosphoSite-P20142
TrEMBL
UniProt Splice Variant
Entrez Gene 5225
UniGene
RefSeq NP_002621
HUGO HGNC:8890
OMIM 169740
CCDS CCDS4859
HPRD 01357
IMGT
EMBL AK301298 AL365205 BC073740 J04443 M18659 M18660 M18661 M18662 M18663 M18664 M18665 M18666 M18667 M23069 M23070 M23071 M23072 M23073 M23074 M23075 M23077 U75272
GenPept AAA60062 AAA60063 AAA60074 AAB18273 AAH73740 BAG62855 CAI13181

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca