InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIME1

Summary

InnateDB Protein

IDBP-87259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIME1

Protein Name

Lck interacting transmembrane adaptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309521

InnateDB Gene

IDBG-87257 (LIME1)

Protein Structure

UniProt Annotation

Function

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269PubMed:14610046}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046}; Single-pass type III membrane protein {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.

Disease Associations

Tissue Specificity

Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level). {ECO:0000269PubMed:14610044, ECO:0000269PubMed:14610046, ECO:0000269PubMed:16160011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process