InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIZ1

Summary

InnateDB Protein

IDBP-87527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIZ1

Protein Name

CDKN1A interacting zinc finger protein 1

Synonyms

LSFR1; NP94; ZNF356;

Species

Homo sapiens

Ensembl Protein

ENSP00000362029

InnateDB Gene

IDBG-87513 (CIZ1)

Protein Structure

UniProt Annotation

Function

May regulate the subcellular localization of CIP/WAF1.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000690 Zinc finger, C2H2-type matrin
IPR003604 Zinc finger, U1-type
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding

PFAM

PF12171

PRINTS

PIRSF

SMART

SM00451
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ULV3