InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRS3

Summary

InnateDB Protein

IDBP-87580.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRS3

Protein Name

bombesin-like receptor 3

Synonyms

BB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000359682

InnateDB Gene

IDBG-87578 (BRS3)

Protein Structure

UniProt Annotation

Function

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In germ cells in testis. Lung carcinoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004946	bombesin receptor activity

Biological Process

GO:0006006	glucose metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0008343	adult feeding behavior
GO:0031989	bombesin receptor signaling pathway
GO:0045087	innate immune response

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001556 Bombesin receptor
IPR001560 Bombesin receptor type 3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR01012
PR00358
PR00637

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32247