InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGPP1

Summary

InnateDB Protein

IDBP-8769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGPP1

Protein Name

sphingosine-1-phosphate phosphatase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000247225

InnateDB Gene

IDBG-8767 (SGPP1)

Protein Structure

UniProt Annotation

Function

Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. {ECO:0000269PubMed:12815058}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12815058}; Multi-pass membrane protein {ECO:0000269PubMed:12815058}.

Disease Associations

Tissue Specificity

Ubiquitous, with the strongest level in placenta and kidney. {ECO:0000269PubMed:12815058}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0042392	sphingosine-1-phosphate phosphatase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006668	sphinganine-1-phosphate metabolic process
GO:0006670	sphingosine metabolic process
GO:0016311	dephosphorylation
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway