Homo sapiens Protein: ATP11C
Summary
InnateDB Protein IDBP-87953.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP11C
Protein Name ATPase, class VI, type 11C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359588
InnateDB Gene IDBG-87951 (ATP11C)
Protein Structure
UniProt Annotation
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21914794}; Multi-pass membrane protein {ECO:0000269PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269PubMed:21914794}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15533723}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004012 phospholipid-translocating ATPase activity
GO:0005524 ATP binding
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 cation transport
GO:0015914 phospholipid transport
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
PFAM PF00122
PF00702
PF08282
PF13419
PRINTS PR00119
PR00120
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q8NB49
TrEMBL
UniProt Splice Variant
Entrez Gene 286410
UniGene Hs.88252
RefSeq XP_006724814
HUGO HGNC:13554
OMIM 300516
CCDS
HPRD 09814
IMGT
EMBL
GenPept