Homo sapiens Protein: ATP11C | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-87955.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ATP11C | ||||||||||||||||||
Protein Name | ATPase, class VI, type 11C | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000332756 | ||||||||||||||||||
InnateDB Gene | IDBG-87951 (ATP11C) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:21914794}; Multi-pass membrane protein {ECO:0000269PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269PubMed:21914794}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15533723}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001757
Cation-transporting P-type ATPase IPR006539 Cation-transporting P-type ATPase, subfamily IV IPR008250 P-type ATPase, A domain IPR023214 HAD-like domain IPR023299 P-type ATPase, cytoplasmic domain N |
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PFAM |
PF00122
PF00702 PF08282 PF13419 |
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PRINTS |
PR00119
PR00120 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q8NB49 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q8NB49 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 286410 | ||||||||||||||||||
UniGene | Hs.88252 | ||||||||||||||||||
RefSeq | NP_775965 | ||||||||||||||||||
HUGO | HGNC:13554 | ||||||||||||||||||
OMIM | 300516 | ||||||||||||||||||
CCDS | CCDS14668 | ||||||||||||||||||
HPRD | 09814 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AJ580093 AJ580094 AK091552 AK125474 AK125986 AK131262 AL161777 AL356785 AL590077 | ||||||||||||||||||
GenPept | BAC03692 BAC86172 BAC86377 BAD18440 CAE30472 CAE30473 CAI39713 CAI39714 CAI39716 CAI40418 CAI41444 CAI41445 CAI41446 CAI41447 | ||||||||||||||||||