InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKL1

Summary

InnateDB Protein

IDBP-8804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKL1

Protein Name

megakaryoblastic leukemia (translocation) 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347847

InnateDB Gene

IDBG-8802 (MKL1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19350017, ECO:0000269PubMed:24440334}. Cytoplasm {ECO:0000250}. Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (PubMed:24440334). {ECO:0000269PubMed:24440334}.

Disease Associations

Note=A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

Tissue Specificity

Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	15 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005515	protein binding
GO:0043522	leucine zipper domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010735	positive regulation of transcription via serum response element binding
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:2001234	negative regulation of apoptotic signaling pathway