InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AS3MT

Summary

InnateDB Protein

IDBP-88232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AS3MT

Protein Name

arsenic (+3 oxidation state) methyltransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358896

InnateDB Gene

IDBG-233385 (AS3MT)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0030791	arsenite methyltransferase activity
GO:0030792	methylarsonite methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0009404	toxin metabolic process
GO:0018872	arsonoacetate metabolic process
GO:0032259	methylation

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR007823 Methyltransferase-related
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01135
PF01209
PF05148
PF08241
PF08242

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HBK9

PhosphoSite