Version 5.4
Homo sapiens Protein: MAD2L1BP
Summary
InnateDB Protein IDBP-88594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAD2L1BP
Protein Name MAD2L1 binding protein
Synonyms CMT2;
Species Homo sapiens
Ensembl Protein ENSP00000361244
InnateDB Gene IDBG-88590 (MAD2L1BP)
Protein Structure
UniProt Annotation
Function May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269PubMed:18022368}.
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007093 mitotic cell cycle checkpoint
GO:0007096 regulation of exit from mitosis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR009511 Mad1/Cdc20-bound-Mad2 binding protein
PFAM PF06581
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15013
PhosphoSite PhosphoSite-Q15013
TrEMBL
UniProt Splice Variant
Entrez Gene 9587
UniGene Hs.715485
RefSeq NP_055443
HUGO HGNC:21059
OMIM
CCDS CCDS4904
HPRD 10065
IMGT
EMBL AK297172 AL136131 AL353602 AL537692 BC002904 CR456893 D14811
GenPept AAH02904 BAA03552 BAG59665 CAC19507 CAG33174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca