Version 5.4
Homo sapiens Protein: SH3PXD2A
Summary
InnateDB Protein IDBP-88613.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3PXD2A
Protein Name SH3 and PX domains 2A
Synonyms FISH; SH3MD1; TKS5;
Species Homo sapiens
Ensembl Protein ENSP00000348215
InnateDB Gene IDBG-88609 (SH3PXD2A)
Protein Structure
UniProt Annotation
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. {ECO:0000269PubMed:12615925, ECO:0000269PubMed:15710328, ECO:0000269PubMed:15710903, ECO:0000269PubMed:19755710, ECO:0000269PubMed:20609497}.
Subcellular Localization Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Disease Associations
Tissue Specificity Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269PubMed:15710328}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF00787
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TCZ1
PhosphoSite PhosphoSite-Q5TCZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 9644
UniGene Hs.730611
RefSeq NP_055446
HUGO HGNC:23664
OMIM
CCDS CCDS31278
HPRD 10228
IMGT
EMBL AB007878 AL121929 AL133355 CH471066
GenPept BAA24848 CAI13961 CAI13962 CAI13963 CAI15351 CAI15352 EAW49623 EAW49624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca