Version 5.4
Homo sapiens Protein: MAGEA11
Summary
InnateDB Protein IDBP-88636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGEA11
Protein Name melanoma antigen family A, 11
Synonyms CT1.11; MAGE-11; MAGE11; MAGEA-11;
Species Homo sapiens
Ensembl Protein ENSP00000347358
InnateDB Gene IDBG-88634 (MAGEA11)
Protein Structure
UniProt Annotation
Function Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269PubMed:15684378}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15684378}. Cytoplasm {ECO:0000269PubMed:15684378}.
Disease Associations
Tissue Specificity Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue. {ECO:0000269PubMed:15684378}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
Experimentally validated
Total 90 [view]
Protein-Protein 90 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
IPR021072 Melanoma associated antigen, MAGE, N-terminal
PFAM PF01454
PF12440
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43364
PhosphoSite PhosphoSite-P43364
TrEMBL
UniProt Splice Variant
Entrez Gene 4110
UniGene Hs.670252
RefSeq NP_005357
HUGO HGNC:6798
OMIM 300344
CCDS CCDS48180
HPRD 02281
IMGT
EMBL AK127849 AY747607 BC004479 U10686
GenPept AAA68870 AAH04479 AAW71787 BAC87161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca