InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZER1

Summary

InnateDB Protein

IDBP-88662.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZER1

Protein Name

zer-1 homolog (C. elegans)

Synonyms

C9orf60; ZYG; ZYG11BL;

Species

Homo sapiens

Ensembl Protein

ENSP00000291900

InnateDB Gene

IDBG-88660 (ZER1)

Protein Structure

UniProt Annotation

Function

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC. {ECO:0000269PubMed:17304241}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas. {ECO:0000269PubMed:11719588}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0051438	regulation of ubiquitin-protein ligase activity

Cellular Component

GO:0031462

Cul2-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR016024 Armadillo-type fold

PFAM

PF00514

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z7L7

PhosphoSite

PhosphoSite-Q7Z7L7

TrEMBL

X6RD87

UniProt Splice Variant

Entrez Gene

10444

UniGene

Hs.147950

RefSeq

NP_006327

HUGO

HGNC:30960

OMIM

CCDS

CCDS6910

HPRD

10802

IMGT

EMBL

AL441992 BC033884 BC052563 CH471090 X99802

GenPept

AAH33884 AAH52563 CAA68137 CAI15407 CAI15408 CAI15409 EAW87830 EAW87831