Version 5.4
Homo sapiens Protein: CASZ1
Summary
InnateDB Protein IDBP-89094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASZ1
Protein Name castor zinc finger 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366221
InnateDB Gene IDBG-89092 (CASZ1)
Protein Structure
UniProt Annotation
Function Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7. {ECO:0000269PubMed:23639441}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16631614}.
Disease Associations
Tissue Specificity Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain. {ECO:0000269PubMed:16631614}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86V15
PhosphoSite PhosphoSite-Q86V15
TrEMBL
UniProt Splice Variant
Entrez Gene 54897
UniGene Hs.743840
RefSeq NP_001073312
HUGO HGNC:26002
OMIM 609895
CCDS CCDS41246
HPRD 07897
IMGT
EMBL AK000328 AK130996 AL139423 BC004410 BC051883 DQ217660 DQ372703
GenPept AAH04410 AAH51883 ABB29845 ABD14411 BAA91089 BAC85474 CAI22571

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca