InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRAXIN

Summary

InnateDB Protein

IDBP-89567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRAXIN

Protein Name

chromosome 1 open reading frame 187

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294485

InnateDB Gene

IDBG-89565 (DRAXIN)

Protein Structure

UniProt Annotation

Function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255HAMAP- Rule:MF_03060}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007411	axon guidance
GO:0016055	Wnt signaling pathway
GO:0021516	dorsal spinal cord development
GO:0021528	commissural neuron differentiation in spinal cord
GO:0030517	negative regulation of axon extension
GO:0030900	forebrain development
GO:0043524	negative regulation of neuron apoptotic process
GO:0090090	negative regulation of canonical Wnt signaling pathway