InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HABP2

Summary

InnateDB Protein

IDBP-89965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HABP2

Protein Name

hyaluronan binding protein 2

Synonyms

FSAP; HABP; HGFAL; PHBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000277903

InnateDB Gene

IDBG-89961 (HABP2)

Protein Structure

UniProt Annotation

Function

Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. {ECO:0000269PubMed:10754382, ECO:0000269PubMed:11217080, ECO:0000269PubMed:8827452}.

Subcellular Localization

Secreted {ECO:0000269PubMed:8827452}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8827452}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	2 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00008
PF00089
PF07645

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00181
SM00020
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt