InnateDB Protein
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IDBP-90068.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CASP7
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Protein Name
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caspase 7, apoptosis-related cysteine peptidase
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Synonyms
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CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358337
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InnateDB Gene
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IDBG-90066 (CASP7)
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Protein Structure
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Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp--Gly- 217' bond. Overexpression promotes programmed cell death.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
95
[view]
|
Protein-Protein |
94
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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|
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Molecular Function |
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Biological Process |
GO:0006508
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proteolysis
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GO:0006915
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apoptotic process
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GO:0006921
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cellular component disassembly involved in execution phase of apoptosis
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GO:0008635
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activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
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GO:0045087
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innate immune response (InnateDB)
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:0097194
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execution phase of apoptosis
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Cellular Component |
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PDB ID |
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InterPro |
IPR001309
Peptidase C14, ICE, catalytic subunit p20
IPR011600
Peptidase C14, caspase domain
IPR015917
Peptidase C14A, caspase precursor p45, core
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PFAM |
PF00656
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PRINTS |
PR00376
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PIRSF |
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SMART |
SM00115
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TIGRFAMs |
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Modification |
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SwissProt |
P55210
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PhosphoSite |
PhosphoSite-P55210
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
840
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UniGene |
Hs.9216
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RefSeq |
NP_203126
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HUGO |
HGNC:1508
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OMIM |
601761
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CCDS |
CCDS7582
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HPRD |
03457
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IMGT |
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EMBL |
AB451281
AB451413
AK298964
AL592546
AL627395
BC015799
BT006683
CH471066
U37448
U37449
U39613
U40281
U67206
U67319
U67320
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GenPept |
AAC50303
AAC50304
AAC50346
AAC50352
AAC51152
AAC51153
AAF21460
AAH15799
AAP35329
BAG61059
BAG70095
BAG70227
CAI12638
CAI12639
CAI16004
CAI16005
EAW49494
EAW49495
EAW49496
EAW49497
EAW49498
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