InnateDB Protein
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IDBP-90374.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AFAP1L2
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Protein Name
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actin filament associated protein 1-like 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358276
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InnateDB Gene
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IDBG-90372 (AFAP1L2)
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Protein Structure
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Function |
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269PubMed:17412687}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:17412687}.
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Disease Associations |
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Tissue Specificity |
Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. {ECO:0000269PubMed:17412687}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006954
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inflammatory response
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GO:0007346
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regulation of mitotic cell cycle
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GO:0032675
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regulation of interleukin-6 production
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GO:0032757
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positive regulation of interleukin-8 production
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GO:0045742
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positive regulation of epidermal growth factor receptor signaling pathway
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0061098
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positive regulation of protein tyrosine kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N4X5
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PhosphoSite |
PhosphoSite-Q8N4X5
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TrEMBL |
B7Z363
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UniProt Splice Variant |
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Entrez Gene |
84632
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UniGene |
Hs.501106
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RefSeq |
NP_115939
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HUGO |
HGNC:25901
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OMIM |
612420
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CCDS |
CCDS31287
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HPRD |
13902
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IMGT |
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EMBL |
AB067501
AC005383
AF474151
AK027470
AK123108
AK291712
AK295538
AL133384
AL355302
BC024314
BC033212
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GenPept |
AAH24314
AAH33212
AAQ05765
BAB55135
BAB67807
BAF84401
BAG53870
BAH12099
CAI14967
CAI14968
CAI40128
CAI40129
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