Version 5.4
Homo sapiens Protein: PAQR8
Summary
InnateDB Protein IDBP-90614.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAQR8
Protein Name progestin and adipoQ receptor family member VIII
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353953
InnateDB Gene IDBG-90610 (PAQR8)
Protein Structure
UniProt Annotation
Function Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11676489}; Multi-pass membrane protein {ECO:0000269PubMed:11676489}. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D.
Disease Associations
Tissue Specificity Expressed in brain and spinal cord. Also expressed in kidney and testis. {ECO:0000269PubMed:11676489, ECO:0000269PubMed:12601167, ECO:0000269PubMed:16044242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003707 steroid hormone receptor activity
GO:0005496 steroid binding
Biological Process
GO:0007275 multicellular organismal development
GO:0043401 steroid hormone mediated signaling pathway
GO:0048477 oogenesis
GO:0048545 response to steroid hormone
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004254 Hly-III-related
IPR016187 C-type lectin fold
PFAM PF03006
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TEZ7
PhosphoSite PhosphoSite-
TrEMBL D6RCM7
UniProt Splice Variant
Entrez Gene 85315
UniGene Hs.239388
RefSeq
HUGO HGNC:15708
OMIM 607780
CCDS CCDS4941
HPRD 07415
IMGT
EMBL AF313619 AF347029 AK315088 AL136125 AL138722 AY424286 BC030664 CH471081
GenPept AAH30664 AAL79777 AAO47232 AAR08374 BAG37553 CAC05478 EAX04368 EAX04369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca