InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PNLIPRP1

Summary

InnateDB Protein

IDBP-90664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNLIPRP1

Protein Name

pancreatic lipase-related protein 1

Synonyms

PLRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000351695

InnateDB Gene

IDBG-90660 (PNLIPRP1)

Protein Structure

UniProt Annotation

Function

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:1379598, ECO:0000269PubMed:19824014}.

Disease Associations

Tissue Specificity

Pancreas. {ECO:0000269PubMed:1379598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006629

lipid metabolic process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00823

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References