InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDX3

Summary

InnateDB Protein

IDBP-91078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX3

Protein Name

peroxiredoxin 3

Synonyms

AOP-1; AOP1; HBC189; MER5; PRO1748; prx-III; SP-22;

Species

Homo sapiens

Ensembl Protein

ENSP00000298510

InnateDB Gene

IDBG-91076 (PRDX3)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. {ECO:0000269PubMed:12492477}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008379	thioredoxin peroxidase activity
GO:0008785	alkyl hydroperoxide reductase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051920	peroxiredoxin activity

Biological Process

GO:0001893	maternal placenta development
GO:0006979	response to oxidative stress
GO:0007005	mitochondrion organization
GO:0008284	positive regulation of cell proliferation
GO:0018171	peptidyl-cysteine oxidation
GO:0030099	myeloid cell differentiation
GO:0032496	response to lipopolysaccharide
GO:0033673	negative regulation of kinase activity
GO:0034599	cellular response to oxidative stress
GO:0034614	cellular response to reactive oxygen species
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005769	early endosome
GO:0005829	cytosol
GO:0008385	IkappaB kinase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM