InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP5F

Summary

InnateDB Protein

IDBP-91244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5F

Protein Name

inositol polyphosphate-5-phosphatase F

Synonyms

hSAC2; MSTPO47; SAC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000354519

InnateDB Gene

IDBG-91238 (INPP5F)

Protein Structure

UniProt Annotation

Function

Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5- bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. {ECO:0000269PubMed:11274189, ECO:0000269PubMed:17322895}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11274189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042578	phosphoric ester hydrolase activity

Biological Process

GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0031161	phosphatidylinositol catabolic process
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051896	regulation of protein kinase B signaling