InnateDB Protein
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IDBP-91276.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MCMBP
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Protein Name
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minichromosome maintenance complex binding protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000353098
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InnateDB Gene
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IDBG-91272 (MCMBP)
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Protein Structure
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Function |
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269PubMed:20090939, ECO:0000269PubMed:21196493}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17296731}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019140
Mini-chromosome maintenance complex-binding protein
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PFAM |
PF09739
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BTE3
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PhosphoSite |
PhosphoSite-Q9BTE3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79892
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UniGene |
Hs.693133
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RefSeq |
NP_079110
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HUGO |
HGNC:25782
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OMIM |
610909
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CCDS |
CCDS7617
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HPRD |
07624
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IMGT |
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EMBL |
AC027672
AK023143
AK094075
BC000935
BC004183
BC007219
CR457299
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GenPept |
AAH00935
AAH04183
AAH07219
BAB14427
BAG52809
CAG33580
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