Version 5.4
Homo sapiens Protein: MCMBP
Summary
InnateDB Protein IDBP-91278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCMBP
Protein Name minichromosome maintenance complex binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358073
InnateDB Gene IDBG-91272 (MCMBP)
Protein Structure
UniProt Annotation
Function Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269PubMed:20090939, ECO:0000269PubMed:21196493}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17296731}. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000084 mitotic S phase
GO:0006261 DNA-dependent DNA replication
GO:0007062 sister chromatid cohesion
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0042555 MCM complex
Protein Structure and Domains
PDB ID
InterPro IPR019140 Mini-chromosome maintenance complex-binding protein
PFAM PF09739
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BTE3
PhosphoSite PhosphoSite-Q9BTE3
TrEMBL
UniProt Splice Variant
Entrez Gene 79892
UniGene Hs.693133
RefSeq NP_001243308
HUGO HGNC:25782
OMIM 610909
CCDS CCDS58099
HPRD 07624
IMGT
EMBL AC027672 AK023143 AK094075 BC000935 BC004183 BC007219 CR457299
GenPept AAH00935 AAH04183 AAH07219 BAB14427 BAG52809 CAG33580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca