InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PADI2

Summary

InnateDB Protein

IDBP-91744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PADI2

Protein Name

peptidyl arginine deiminase, type II

Synonyms

PAD-H19; PAD2; PDI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000364635

InnateDB Gene

IDBG-91742 (PADI2)

Protein Structure

UniProt Annotation

Function

Catalyzes the deimination of arginine residues of proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12392711}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004668	protein-arginine deiminase activity
GO:0005509	calcium ion binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0010848	regulation of chromatin disassembly
GO:0018101	protein citrullination
GO:0021762	substantia nigra development
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0036413	histone H3-R26 citrullination
GO:0048096	chromatin-mediated maintenance of transcription
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:1901624	negative regulation of lymphocyte chemotaxis

Cellular Component

GO:0005737	cytoplasm
GO:0035327	transcriptionally active chromatin
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008972 Cupredoxin
IPR013530 Protein-arginine deiminase, C-terminal
IPR013732 Protein-arginine deiminase (PAD) N-terminal
IPR013733 Protein-arginine deiminase (PAD), central domain
IPR016296 Protein-arginine deiminase, subgroup

PFAM

PF03068
PF08526
PF08527

PRINTS

PIRSF

PIRSF001247

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y2J8