InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RCC2

Summary

InnateDB Protein

IDBP-91843.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCC2

Protein Name

regulator of chromosome condensation 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364585

InnateDB Gene

IDBG-91841 (RCC2)

Protein Structure

UniProt Annotation

Function

Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. {ECO:0000269PubMed:12919680}.

Subcellular Localization

Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0044822	poly(A) RNA binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007032	endosome organization
GO:0007067	mitotic nuclear division
GO:0007229	integrin-mediated signaling pathway
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0030334	regulation of cell migration
GO:0034260	negative regulation of GTPase activity
GO:0048041	focal adhesion assembly
GO:0051895	negative regulation of focal adhesion assembly
GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore
GO:0072356	chromosome passenger complex localization to kinetochore
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0030496	midbody
GO:0034506	chromosome, centromeric core region
GO:1990023	mitotic spindle midzone