InnateDB Protein
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IDBP-91845.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RCC2
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Protein Name
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regulator of chromosome condensation 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364582
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InnateDB Gene
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IDBG-91841 (RCC2)
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Protein Structure
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Function |
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1. {ECO:0000269PubMed:12919680}.
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Subcellular Localization |
Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000278
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mitotic cell cycle
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GO:0007032
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endosome organization
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GO:0007067
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mitotic nuclear division
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GO:0007229
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integrin-mediated signaling pathway
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GO:0010971
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positive regulation of G2/M transition of mitotic cell cycle
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GO:0030334
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regulation of cell migration
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GO:0034260
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negative regulation of GTPase activity
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GO:0048041
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focal adhesion assembly
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GO:0051895
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negative regulation of focal adhesion assembly
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GO:0051987
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positive regulation of attachment of spindle microtubules to kinetochore
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GO:0072356
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chromosome passenger complex localization to kinetochore
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GO:1900025
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negative regulation of substrate adhesion-dependent cell spreading
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Cellular Component |
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PDB ID |
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InterPro |
IPR000408
Regulator of chromosome condensation, RCC1
IPR009091
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
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PFAM |
PF00415
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PRINTS |
PR00633
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P258
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PhosphoSite |
PhosphoSite-Q9P258
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TrEMBL |
A0A024RAC5
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UniProt Splice Variant |
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Entrez Gene |
55920
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UniGene |
Hs.545187
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RefSeq |
NP_001129676
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HUGO |
HGNC:30297
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OMIM |
609587
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CCDS |
CCDS181
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HPRD |
18171
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IMGT |
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EMBL |
AB040903
AJ421269
AL359612
BC004933
BC042141
BC053908
CH471134
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GenPept |
AAH04933
AAH42141
AAH53908
BAA95994
CAB94882
CAD13148
EAW94838
EAW94839
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