InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBAC1

Summary

InnateDB Protein

IDBP-92159.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBAC1

Protein Name

UBA domain containing 1

Synonyms

GBDR1; UBADC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000360821

InnateDB Gene

IDBG-92157 (UBAC1)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. {ECO:0000269PubMed:15531880, ECO:0000269PubMed:15746103}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10857748, ECO:0000269PubMed:15531880}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10857748}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0016567

protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029071 Ubiquitin-related domain

PFAM

PF00627

PRINTS

PIRSF

SMART

SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BSL1