InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPRY3

Summary

InnateDB Protein

IDBP-92543.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRY3

Protein Name

sprouty homolog 3 (Drosophila)

Synonyms

HSPRY3; spry-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000302978

InnateDB Gene

IDBG-92541 (SPRY3)

Protein Structure

UniProt Annotation

Function

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Disease Associations

Tissue Specificity

Widely expressed; particularly in the fetal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007875 Sprouty

PFAM

PF05210

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43610

PhosphoSite

PhosphoSite-O43610

TrEMBL

UniProt Splice Variant

Entrez Gene

10251

UniGene

Hs.602892

RefSeq

NP_005831

HUGO

HGNC:11271

OMIM

300531

CCDS

CCDS14769

HPRD

03917

IMGT

EMBL

AF041038 AJ271735 AK289543 BC069609 BC074972 BC074973 CH471247

GenPept

AAC39567 AAH69609 AAH74972 AAH74973 BAF82232 CAB96768 EAW55876