Version 5.4
Homo sapiens Protein: FAM175B
Summary
InnateDB Protein IDBP-92729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM175B
Protein Name family with sequence similarity 175, member B
Synonyms ABRO1; KIAA0157;
Species Homo sapiens
Ensembl Protein ENSP00000298492
InnateDB Gene IDBG-92727 (FAM175B)
Protein Structure
UniProt Annotation
Function Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
Biological Process
GO:0071497 cellular response to freezing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070552 BRISC complex
Protein Structure and Domains
PDB ID
InterPro IPR023238 FAM175 family
IPR023240 FAM175 family, BRISC complex, Abro1 subunit
PFAM
PRINTS PR02051
PR02053
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15018
PhosphoSite PhosphoSite-Q15018
TrEMBL
UniProt Splice Variant
Entrez Gene 23172
UniGene Hs.717650
RefSeq NP_115558
HUGO HGNC:28975
OMIM 611144
CCDS CCDS31308
HPRD 13783
IMGT
EMBL AK296677 BC008999 D63877
GenPept AAH08999 BAA09927 BAG59274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca