Version 5.4
Homo sapiens Protein: EDF1
Summary
InnateDB Protein IDBP-92788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDF1
Protein Name endothelial differentiation-related factor 1
Synonyms EDF-1; MBF1;
Species Homo sapiens
Ensembl Protein ENSP00000360712
InnateDB Gene IDBG-92784 (EDF1)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269PubMed:10567391, ECO:0000269PubMed:12040021, ECO:0000269PubMed:15112053, ECO:0000269PubMed:9813014}.
Subcellular Localization Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Disease Associations
Tissue Specificity Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. {ECO:0000269PubMed:10567391, ECO:0000269PubMed:12040021, ECO:0000269PubMed:9813014}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001387 Cro/C1-type helix-turn-helix domain
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013729 Multiprotein bridging factor 1, N-terminal
PFAM PF01381
PF13443
PF13413
PF08523
PRINTS
PIRSF
SMART SM00530
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-O60869
TrEMBL
UniProt Splice Variant
Entrez Gene 8721
UniGene Hs.174050
RefSeq NP_001268226
HUGO HGNC:3164
OMIM 605107
CCDS CCDS65193
HPRD 09235
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca