InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELL3

Summary

InnateDB Protein

IDBP-9280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELL3

Protein Name

elongation factor RNA polymerase II-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320346

InnateDB Gene

IDBG-9276 (ELL3)

Protein Structure

UniProt Annotation

Function

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). {ECO:0000250, ECO:0000269PubMed:10882741, ECO:0000269PubMed:22195968}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10882741}.

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:10882741}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035326	enhancer binding

Biological Process

GO:0006354	DNA-dependent transcription, elongation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048863	stem cell differentiation
GO:0050769	positive regulation of neurogenesis
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179	positive regulation of neural precursor cell proliferation