InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF2

Summary

InnateDB Protein

IDBP-92821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF2

Protein Name

TNF receptor-associated factor 2

Synonyms

MGC:45012; TRAP; TRAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000247668

InnateDB Gene

IDBG-92817 (TRAF2)

Protein Structure

UniProt Annotation

Function

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269PubMed:10346818, ECO:0000269PubMed:11907583, ECO:0000269PubMed:12917689, ECO:0000269PubMed:15121867, ECO:0000269PubMed:15383523, ECO:0000269PubMed:18981220, ECO:0000269PubMed:19150425, ECO:0000269PubMed:19506082, ECO:0000269PubMed:19810754, ECO:0000269PubMed:19918265, ECO:0000269PubMed:19937093, ECO:0000269PubMed:20047764, ECO:0000269PubMed:20064526, ECO:0000269PubMed:20385093, ECO:0000269PubMed:20577214, ECO:0000269PubMed:23453969}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15383523, ECO:0000269PubMed:19150425}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 392 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Experimentally validated
Total	392 [view]
Protein-Protein	389 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0046625	sphingolipid binding
GO:0046872	metal ion binding

Biological Process

GO:0002726	positive regulation of T cell cytokine production
GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0030163	protein catabolic process
GO:0032743	positive regulation of interleukin-2 production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034351	negative regulation of glial cell apoptotic process
GO:0042981	regulation of apoptotic process
GO:0043507	positive regulation of JUN kinase activity
GO:0043623	cellular protein complex assembly
GO:0045087	innate immune response (InnateDB)
GO:0046328	regulation of JNK cascade
GO:0050870	positive regulation of T cell activation
GO:0051023	regulation of immunoglobulin secretion
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051291	protein heterooligomerization
GO:0051865	protein autoubiquitination
GO:0070207	protein homotrimerization
GO:0070534	protein K63-linked ubiquitination
GO:0071732	cellular response to nitric oxide
GO:0090073	positive regulation of protein homodimerization activity
GO:0097190	apoptotic signaling pathway
GO:0097300	programmed necrotic cell death
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0009898	cytoplasmic side of plasma membrane
GO:0035631	CD40 receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR001293 Zinc finger, TRAF-type
IPR001841 Zinc finger, RING-type
IPR002083 MATH
IPR008974 TRAF-like
IPR012227 TNF receptor-associated factor TRAF
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00917
PF00097

PRINTS

PIRSF

PIRSF015614

SMART

SM00184
SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt