InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C8G

Summary

InnateDB Protein

IDBP-92882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C8G

Protein Name

complement component 8, gamma polypeptide

Synonyms

C8C;

Species

Homo sapiens

Ensembl Protein

ENSP00000224181

InnateDB Gene

IDBG-92880 (C8G)

Protein Structure

UniProt Annotation

Function

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0019841	retinol binding
GO:0032403	protein complex binding

Biological Process

GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0019835	cytolysis
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005579	membrane attack complex
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle