InnateDB Protein
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IDBP-93048.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM30A
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Protein Name
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transmembrane protein 30A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230461
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InnateDB Gene
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IDBG-93044 (TMEM30A)
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Protein Structure
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Function |
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet- activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269PubMed:20510206, ECO:0000269PubMed:20947505, ECO:0000269PubMed:20961850, ECO:0000269PubMed:21289302}.
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Subcellular Localization |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006855
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drug transmembrane transport
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GO:0010976
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positive regulation of neuron projection development
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GO:0036010
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protein localization to endosome
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GO:0045332
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phospholipid translocation
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GO:0070863
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positive regulation of protein exit from endoplasmic reticulum
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Cellular Component |
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PDB ID |
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InterPro |
IPR005045
CDC50/LEM3 family
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PFAM |
PF03381
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PRINTS |
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PIRSF |
PIRSF015840
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NV96
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PhosphoSite |
PhosphoSite-Q9NV96
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TrEMBL |
E5RG19
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UniProt Splice Variant |
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Entrez Gene |
55754
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UniGene |
Hs.630824
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RefSeq |
NP_060717
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HUGO |
HGNC:16667
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OMIM |
611028
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CCDS |
CCDS4983
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HPRD |
15535
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IMGT |
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EMBL |
AK001718
AK292823
AL080250
AL162046
AL832490
AL832815
BC009006
CH471051
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GenPept |
AAH09006
BAA91859
BAF85512
CAB82389
CAH56205
CAH56262
CAI19900
EAW48743
EAW48744
EAW48745
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