InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COBRA1

Summary

InnateDB Protein

IDBP-93319.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COBRA1

Protein Name

cofactor of BRCA1

Synonyms

COBRA1; NELF-B;

Species

Homo sapiens

Ensembl Protein

ENSP00000339495

InnateDB Gene

IDBG-93317 (COBRA1)

Protein Structure

UniProt Annotation

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. {ECO:0000269PubMed:10199401, ECO:0000269PubMed:12612062}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11739404}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:12612062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050434	positive regulation of viral transcription